Search results for "Amanita muscaria"

showing 5 items of 5 documents

Mannitol in Amanita muscaria – An osmotic blood–brain barrier disruptor enhancing its hallucinogenic action?

2013

Hypothesis have been made that relatively high level of mannitol present in the tissues of fly agaric (Amanita muscaria) enables more efficient transportation of these active substances into the brain and thus enhance their total activity. It may have been supported by the fact that hallucinogenic effect after A. muscaria consumption is greater than after ingestion of an active substance quantity which the eaten fungi dose contain.

HallucinogenMagnetic Resonance SpectroscopyInjury controlAmanitaPoison controlComplex MixturesPharmacologyBlood–brain barrierToxicologyOsmoregulationSpecies SpecificityHumansMedicineIngestionMannitolbiologybusiness.industryAgaricBrainGeneral Medicinebiology.organism_classificationmedicine.anatomical_structureHallucinogensMannitolbusinessAmanita muscariamedicine.drugMedical Hypotheses
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Theoretical and experimental NMR studies on muscimol from fly agaric mushroom (Amanita muscaria)

2015

In this article we report results of combined theoretical and experimental NMR studies on muscimol, the bioactive alkaloid from fly agaric mushroom (Amanita muscaria). The assignment of (1)H and (13)C NMR spectra of muscimol in DMSO-d6 was supported by additional two-dimensional heteronuclear correlated spectra (2D NMR) and gauge independent atomic orbital (GIAO) NMR calculations using density functional theory (DFT). The effect of solvent in theoretical calculations was included via polarized continuum model (PCM) and the hybrid three-parameter B3LYP density functional in combination with 6-311++G(3df,2pd) basis set enabled calculation of reliable structures of non-ionized (neutral) molecu…

Magnetic Resonance SpectroscopyAmanitaProton Magnetic Resonance SpectroscopyFluorine-19 NMR010402 general chemistry01 natural sciencesAnalytical ChemistryComputational chemistryDimethyl SulfoxideCarbon-13 Magnetic Resonance SpectroscopyInstrumentationSpectroscopybiologyMuscimol010405 organic chemistryChemistryChemical shiftNuclear magnetic resonance spectroscopyCarbon-13 NMRbiology.organism_classificationAtomic and Molecular Physics and Optics0104 chemical sciencesSolutionsNMR spectra databaseHeteronuclear moleculeThermodynamicsGasesTwo-dimensional nuclear magnetic resonance spectroscopyAmanita muscariaSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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What is the form of muscimol from fly agaric mushroom (Amanita muscaria) in water? An insight from NMR experiment supported by molecular modeling.

2020

ARTYKUŁ Z BADAŃ SPECJALNYCH

Models MolecularMagnetic Resonance SpectroscopyAmanita010402 general chemistry01 natural scienceschemistry.chemical_compoundReceptors GABAComputational chemistryMoleculeHumansGeneral Materials ScienceGABA-A Receptor Antagonistsindirect spin‐spin coupling constantsNMR in waterDensity Functional TheoryCarbon Isotopesbiology010405 organic chemistryAgaricmolecular modelingMuscimolChemical shiftWaterGeneral ChemistryCarbon-13 NMRbiology.organism_classification0104 chemical sciencesSolventnervous systemchemistryMuscimolGIAO NMRZwitterionProtonsAmanita muscariaMagnetic resonance in chemistry : MRCREFERENCES
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Do differences in chemical composition of stem and cap of Amanita muscaria fruiting bodies correlate with topsoil type?

2014

Fly agaric (Amanita muscaria) was investigated using a 1H NMR-based metabolomics approach. The caps and stems were studied separately, revealing different metabolic compositions. Additionally, multivariate data analyses of the fungal basidiomata and the type of soil were performed. Compared to the stems, A. muscaria caps exhibited higher concentrations of isoleucine, leucine, valine, alanine, aspartate, asparagine, threonine, lipids (mainly free fatty acids), choline, glycerophosphocholine (GPC), acetate, adenosine, uridine, 4-aminobutyrate, 6-hydroxynicotinate, quinolinate, UDP-carbohydrate and glycerol. Conversely, they exhibited lower concentrations of formate, fumarate, trehalose, α- an…

PhytochemistryAmanitaFungal Physiologylcsh:MedicineSoil SciencePhenylalanineMycologyPlant ScienceBiologyBiochemistryMicrobiologyAnalytical Chemistrychemistry.chemical_compoundSoilValineMicrobial PhysiologyMolecular Cell BiologyAsparagineFruiting Bodies Fungallcsh:ScienceEcosystemMicrobial MetabolismMultidisciplinaryAgaricSystems Biologylcsh:REcology and Environmental SciencesBiology and Life SciencesAgricultureCell BiologySoil Ecologybiology.organism_classificationQuinolinateTrehaloseChemistryBiochemistrychemistryPhysical Scienceslcsh:QIsoleucineAmanita muscariaResearch ArticlePloS one
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Muchomor czerwony (Amanita muscaria) jako obiecujące źródło ergosterolu

2012

Ergosterol (prowitamina D) jest jednym z głównych składników błon komórkowych grzybów. Ma on obiecujące właściwości immunostymulujące i przeciwrakowe. Muchomor czerwony stanowi bogate źródło ergosterolu, który po ekstrakcji n-heksanem lub octanem etylu łatwo jest otrzymać w formie krystalicznej. Fly agaric was extd. with n-hexane or EtOH optionally under microwave aid to recover ergosta-5,7,22-trien-3β- ol and other steroids. The highest yield was achieved by extn. of the gills, EtOAc was more efficient than n-hexane as a solvent. Ergosterol (ergosta-5,7,22-trien-3β-ol) jest biologicznym prekursorem (prowitaminą) witaminy D2. Jest to główny steryd błon komórkowych grzybów. Ponieważ rzadko w…

przemysł farmaceutycznyergosterolmuchomor czerwonyAmanita muscariafly agaricpharmaceutical industryPrzemysł Chemiczny
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